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Etizolam (marketed under many brand names) is a thienodiazepine derivative which is a benzodiazepine analog. But his molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring and triazole ring has been fused, making the drug a thienotriazolodiazepine.
A thienodiazepine derivative, is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.4 hours.
However, etizolam has not been approved by the FDA for medicinal use , and it cannot be imported, sold or prescribed in the US. In addition, etizolam is marketed in only some countries as a medicinal product
Thienodiazepine possesses potent hypnotic properties, and is comparable with other short-acting benzodiazepines. He acts as a full agonist at the benzodiazepine/GABA a receptor to produce its range of therapeutic and adverse effects.
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According to the Italian prescribing information sheet, thienodiazepine belongs to a new class of diazepines, thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. It has an anxiolytic action about 6-8 times greater than that of diazepam.
However, conflicting reports from the World Health Organization, made public in 1991, dispute the misuse claims
Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time, and a reduction in the number of awakenings. During tests, there were no substantial changes in deep sleep; however, it may reduce REM sleep. In EEG tests of healthy volunteers, it showed some similar characteristics to tricyclic antidepressants